Dr. Zi Chen
As a Branco Weiss fellow, Dr. Zi Chen will investigate how one-dimensional information coded in DNA translates into three-dimensional shapes, and how genetic and epigenetic factors coordinate to create biological form (morphogenesis). Understanding these mechanisms will foster quantitative understanding of plant and animal development, and facilitate biomedical research in preventing and treating congenital diseases. His study will also inspire novel design principles for programmable nanofabrication techniques and bio-mimetic devices.
Dr. Zi Chen's postgraduate research focused on understanding the mechanics of morphogenesis in biological systems, and developing strageties for the design of biomimetic structures or devices.
- Tenure-Track Assistant Professor in Thayer School of Engineering, Dartmouth College, USA from 2015
- Research Scientist in Thayer School of Engineering, Dartmouth College, USA from 2014
- Research Scientist in Biomedical Engineering, Washington University in St. Louis, USA from 2013
- Postdoctoral researcher in Biomedical Engineering, Washington University in St. Louis, USA from 2011
- PhD studies in Mechanical and Aerospace Engineering, Princeton University, USA from 2005
- Masters studies in Materials Physics and Chemistry, Shanghai Jiaotong University, China
- Undergraduate studies in Computer Technology and Applications, Shanghai Jiaotong University, China
- Undergraduate studies in Materials Science and Engineering, Shanghai Jiaotong University, China
- National Insitute of Health U01 sub-award, 2015-2020
- Outstanding Paper Award, ASME 2nd Global Congress on NanoEngineering for Medicine and Biology, 2013
- Young Investigator Award (co-PI), National Science Foundation of China, 2012-2015
- American Academy of Mechanics Founder's Award, 2012
- Silver Medal, Materials Research Society Graduate Student Award, 2012
- Fellowship, NSF-GEM4 Summer School, 2012
- FGSA Travel Award for Excellence in Graduate Research from American Physical Society, Forum on Graduate Student Affairs, 2012
- Sigma Xi GIAR (Grant-in-aid of Research) Award, 2011
- Best Junior Researcher Award (2nd place), 140th TMS annual meeting, 2011
- Best Poster Presentation Award (1st place), Princeton Research Symposium, Princeton University, 2010
- Daniel and Florence Guggenheim Foundation Fellowship, Princeton University, 2006-2007
- Sayre Graduate Prize, Princeton University, 2006
In the News
Society in Science Fellow Since
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
Nature presents fascinating examples of functional geometric structures, often driven by mechanical cues, with properties unparalleled by man-made materials. The study of mechanics and geometry of soft matter in various physical systems will not only foster quantitative understanding of the morphogenesis in plant and animal development, and self-assembly of DNAand nano-materials, but will also inspire novel design principles for programmable nanofabrication techniques and bio-mimetic devices with intelligent, functional responses to environmental stimuli.
Details of Research
Understanding the role of mechanical stresses and strains is key to deciphering morphogenesis and growth in biology. Although there have been many studies at the molecular level, it remains unclear how one-dimensional information coded in DNA translate into three-dimensional shapes. The proposed study on DNA mechanics, morphogenesis, and bio-inspired technology involves the integration of mechanics and geometry albeit in physically different contexts. The progress of mechanics in these aspects will facilitate understanding of fundamental problems in mathematics, physics and biology, as well as advance technology of designing smart, bio-inspired materials and devices with wide applications in nano/bio-technology.